Öz

Tip B laktik asidoz, nadir görülen, hayatı tehdit eden ve hematolojik malignitelerle ilişkilendirilmiş bir tablodur. Bu tablo, hızlı tanı ve tedavi gerektirmesi nedeniyle klinik açıdan büyük önem taşır. Malignitelerle ilişkisinin temelinde Warburg etkisi yer alır. Warburg etkisi, tümör hücrelerinin enerji üretimi için oksidatif fosforilasyon yerine glikoliz yolunu tercih etmesi durumudur ve bu durum ciddi laktik asidoz gelişimine yol açabilir.

Burada Warburg fenomeni ile açıklanabilecek şekilde ciddi laktik asidoz ve hipoglisemi ile başvuran, yoğun bakımda takip edilen ve ardından lenfoma tanısı alan iki vakayı paylaşacağız. Vakaların hızlı ve başarılı bir şekilde yönetilmesini detaylandırarak, Warburg fenomeni ile ilgili literatüre katkıda bulunmayı amaçlıyoruz.

Anahtar Kelimeler: tip B laktik asidoz, hipoglisemi, hematolojik malignite, yoğun bakım

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Nasıl atıf yapılır?

1.
Özdemir ZÖ, Özdemir E, Halaçlı B, Güven G, Topeli A. Laktat yüksekliğinin nadir görülen sebebi: Warburg etkisiyle açıklanan iki lenfoma vakası ve literatür taraması. Turk J Intensive Care. 2025;23(4):326-334. https://doi.org/10.63729/TJIC.2025.677