ABSTRACT

Determining the factors affecting mortality may be pivotal in terms of improving survival in the coronavirus disease-19 (COVID-19). The aim of this study was to determine the demographic, clinical and laboratory characteristics of COVID-19 patients and the factors affecting intensive care unit (ICU) mortality.

It was designed as a retrospective cohort study in which patients with a diagnosis of COVID-19 hospitalized in the ICU. The clinical and laboratory parameters were compared between mortality and survival cohorts. Univariate and multivariate logistic regression analysis were performed for the effect profiles of the parameters on mortality.

The mortality of 58.6% was alike for the three pandemic waves or selected time intervals (p=0.245). Presence of comorbid disease, age, COVID-19 related complications, admission Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) Scores were significantly higher in mortality cohort (p<0.001). The factors influencing mortality according to multivariate logistic regression model were hypertension, malignancy (solid and hematologic), neurological illness, age, APACHE-II and SOFA scores, and neutrophil to lymphocyte ratio.

The patients having these risk factors should be monitored with greater caution in terms of the timing and duration of ICU care.