ABSTRACT

Objective:

In our study, we aimed to investigate the effect of hypothermia on survival, C-reactive protein (CRP), procalcitonin and leukocyte levels in rat models, induced with cecal ligation-perforation procedure.

Materials and Methods:

After formation of the sepsis, the rats were randomized as hypothermic sham, septic (32 °C-34 °C) and normothermic sham, septic (36 °C-38 °C). At the beginning of study (0 h) and at 6^th hour blood was taken from all rats in all groups; CRP, procalcitonin, leukocyte levels were measured and the survival time of rats in all groups was recorded.

Results:

A statistically significant difference was found between the hypothermic and normothermic septic group in terms of survival time (hypothermic septic 24.3±20.2, normothermic septic group 15.9±13.5 h, p=0.039). There was no statistically significant difference for time dependent changes of CRP and procalcitonin all groups.

Conclusion:

It can be suggested that hypothermia in experimental sepsis might have positive effects on survival but the effect on the markers of infection is unclear and further studies are needed.

Keywords: Hypothermia, experimental, Rat model, sepsis

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Protective Effect of Hypothermia During Experimental Sepsis

ABSTRACT

References