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E-ISSN: 2602-2974
COVİD-19 Akut Respiratuvar Distres Sendromu Fenotiplerinde Mekanik Ventilasyon
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Original Research
VOLUME: 20 ISSUE: 1
P: 126-134
March 2022

COVİD-19 Akut Respiratuvar Distres Sendromu Fenotiplerinde Mekanik Ventilasyon

J Turk Soc Intens Care 2022;20(1):126-134
DOI: 10.4274/tybd.galenos.2022.30301
Özgür Kömürcü
Sercan Küllaç
Abdurrahman Yılmaz
Fatma Ülger
1. Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Samsun, Türkiye
No information available.
No information available
Received Date: 11.10.2021
Accepted Date: 25.07.2022
Publish Date: 20.09.2022
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ABSTRACT

Objective:

Coronavirus disease-2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) phenotypes in lung compliance have been described in patients with COVID- 19-related ARDS. Our study examined mechanical ventilation support and its results in patients with COVID-19-related ARDS.

Materials and Methods:

The retrospectively planned study was performed in patients with COVID- 19-associated ARDS who were determined to have three phenotype subgroups based on the calculated static compliance (Cstat) value [type high (H) = Cstat <40 mL/cmH2O, type light (L) = Cstat ≥50 mL/cmH2O and type intermediate (Int) =40≤ Cstat <50 mL/cm H2O]. The effects of mechanical ventilation strategy on the duration of mechanical ventilation, length of stay in the intensive care unit, and mortality in COVID-19 ARDS phenotypes were investigated.

Results:

It was determined that the study patients were 72.3% type H, 23.4% type L, and 4.3% type Int in terms of COVID-19 ARDS phenotype. It was observed that the mechanical ventilation strategy did not affect the duration of mechanical ventilation (p=0.357), the length of stay in the intensive care unit (p=0.127), and the mortality rate (p=0.583) in all three phenotypes.

Conclusion:

We believe that a phenotype-independent protective ventilation strategy defined according to compliance is appropriate in patients with COVID-19-associated ARDS.

Keywords: COVID-19, acute respiratory distress syndrome, mechanical ventilation, phenotype

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