EN | TR
E-ISSN: 2602-2974
Characteristics of Patients with COVID-19 Pneumonia Treated with High-flow Oxygen and Non-invasive Ventilation Outside the Intensive Care Unit
PDF
Cite
Share
Request
Original Research
VOLUME: 21 ISSUE: 3
P: 196-201
September 2023

Characteristics of Patients with COVID-19 Pneumonia Treated with High-flow Oxygen and Non-invasive Ventilation Outside the Intensive Care Unit

J Turk Soc Intens Care 2023;21(3):196-201
DOI: 10.4274/tybd.galenos.2022.98700
Burcu Özdemir 1
Levent Özdemir 1
Mehmet Murat Çelik 2
Senem Urfalı 3
1. Sağlık Bilimleri Üniversitesi, Samsun Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, Samsun, Türkiye
2. Dörtyol Devlet Hastanesi, Anestezi ve Reanimasyon Kliniği, Hatay, Türkiye
3. Hatay Mustafa Kemal Üniversitesi Tayfur Ata Sökmen Tıp Fakültesi, Anestezi ve Reanimasyon Anabilim Dalı, Hatay, Türkiye
No information available.
No information available
Received Date: 25.09.2022
Accepted Date: 24.10.2022
Publish Date: 26.09.2023
PDF
Cite
Share
Request

ABSTRACT

Objective:

Comparing high-flow oxygen (HFO) and non-invasive ventilation (NIV) treatment methods applied to patients hospitalized in the coronavirus disease-2019 (COVID-19) service outside the intensive care unit.

Materials and Methods:

Demographic characteristics, duration of hospitalization and application times, acute phase reactants, ROX index, comorbid conditions, radiological scores and results were evaluated retrospectively in patients treated with HFO (n=26) and NIV (n=23) who were hospitalized in the COVID service outside the intensive care unit of the state hospital between November 2020 and June 2021.

Results:

A total of 49 patients, 27 males and 22 females, were included in the study. The mean age was 55.6±14.6 years. The most common comorbidities were hypertension (n=27), diabetes (n=15). Patients in the HFO group were hospitalized for 16.6±9.4 days, HFO was applied for 6±4.6 days. Patients in the NIV group were hospitalized for 9.4±6.4 days, NIV was applied for 5.8±4.2 days. The saturation of the patients who were administered HFO (84.1±4.6) were found to be lower than those who received NIV (88.7±2). It was determined that 18.37% of 49 patients e.g. 5 of whom were treated with HFO and 4 of them were those who received NIV treatment. The ROX index was found to be significantly lower in the death group (n=9) compared to the survivors (n=40). In radiological imaging, there was no significant difference in the severity of pneumonia in patients treated with HFO and NIV. Lactate dehydrogenase and C-reactive protein from acute phase reactants at the time of hospitalization were significantly higher in the group who ex.

Conclusion:

It was determined that HFO or NIV was not different in terms of mortality in thr non-intensive care COVID service.

Keywords: COVID-19, high-flow oxygen, non-invasive ventilation

References

1
Winck JC, Scala R. Non-invasive respiratory support paths in hospitalized patients with COVID-19: proposal of an algorithm. Pulmonology 2021;27:305-12.
2
Raoof S, Nava S, Carpati C, Hill NS. High-Flow, Noninvasive Ventilation and Awake (Nonintubation) Proning in Patients With Coronavirus Disease 2019 With Respiratory Failure. Chest 2020;158:1992-2002.
3
Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, et al. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med 2019;45:563-72.
4
Caparlar ÖC, Uyar BS. High Flow Nasal Oxygenation and Indications. JARSS 2021;29:211-8
5
Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015;372:2185-96.
6
Winck JC, Ambrosino N. COVID-19 pandemic and non invasive respiratory management: Every Goliath needs a David. An evidence based evaluation of problems. Pulmonology 2020;26:213-20.
7
Grieco DL, Menga LS, Cesarano M, Rosà T, Spadaro S, Bitondo MM, et al. Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial. JAMA 2021;325:1731-43.
8
World Health Organization. Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation-Characteristics of NIV. 2022. Available from: URL: https://www.who.int/publications/m/item/management-of-critical--covid-19-advanced-non-invasive-respiratory-support---high-flow-nasal-oxygen-and-non-invasive-ventilation
9
Pan F, Ye T, Sun P, Gui S, Liang B, Li L, et al. Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID-19). Radiology 2020;295:715-21.
10
T.C. Sağlık Bakanlığı. (2020). COVID-19 (SARS-CoV-2 Enfeksiyonu) Rehberi. https://covid19bilgi.saglik.gov.tr/depo/rehberler/COVID-19_Rehberi.pdf
11
Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, et al. An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy. Am J Respir Crit Care Med 2019;199:1368-76.
12
Li J, Huang DQ, Zou B, Yang H, Hui WZ, Rui F, et al. Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes. J Med Virol 2021;93:1449-58.
13
Beran A, Srour O, Malhas SE, Mhanna M, Ayesh H, Sajdeya O, et al. High-Flow Nasal Cannula Versus Noninvasive Ventilation in Patients With COVID-19. Respir Care 2022;67:1177-89.
14
Peng Y, Dai B, Zhao HW, Wang W, Kang J, Hou HJ, et al. Comparison between high-flow nasal cannula and noninvasive ventilation in COVID-19 patients: a systematic review and meta-analysis. Ther Adv Respir Dis 2022;16:17534666221113663.
15
Duan J, Chen B, Liu X, Shu W, Zhao W, Li J, et al. Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study. Am J Emerg Med 2021;46:276-81.
16
Alharthy A, Faqihi F, Noor A, Soliman I, Brindley PG, Karakitsos D, Memish ZA. Helmet Continuous Positive Airway Pressure in the Treatment of COVID-19 Patients with Acute Respiratory Failure could be an Effective Strategy: A Feasibility Study. J Epidemiol Glob Health 2020;10:201-3.
17
Perkins GD, Ji C, Connolly BA, Couper K, Lall R, Baillie JK, et al. Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial. JAMA 2022;327:546-58.
18
Sykes DL, Crooks MG, Thu Thu K, Brown OI, Tyrer TJP, Rennardson J, et al. Outcomes and characteristics of COVID-19 patients treated with continuous positive airway pressure/high-flow nasal oxygen outside the intensive care setting. ERJ Open Res 2021;7:00318-2021.
19
Zhou X, Liu J, Pan J, Xu Z, Xu J. The ROX index as a predictor of high-flow nasal cannula outcome in pneumonia patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis. BMC Pulm Med 2022;22:121.
2024 ©️ Galenos Publishing House