Abstract

Objective:

Coronavirus disease-2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) phenotypes in lung compliance have been described in patients with COVID- 19-related ARDS. Our study examined mechanical ventilation support and its results in patients with COVID-19-related ARDS.

Materials and Methods:

The retrospectively planned study was performed in patients with COVID- 19-associated ARDS who were determined to have three phenotype subgroups based on the calculated static compliance (Cstat) value [type high (H) = Cstat <40 mL/cmH2O, type light (L) = Cstat ≥50 mL/cmH2O and type intermediate (Int) =40≤ Cstat <50 mL/cm H2O]. The effects of mechanical ventilation strategy on the duration of mechanical ventilation, length of stay in the intensive care unit, and mortality in COVID-19 ARDS phenotypes were investigated.

Results:

It was determined that the study patients were 72.3% type H, 23.4% type L, and 4.3% type Int in terms of COVID-19 ARDS phenotype. It was observed that the mechanical ventilation strategy did not affect the duration of mechanical ventilation (p=0.357), the length of stay in the intensive care unit (p=0.127), and the mortality rate (p=0.583) in all three phenotypes.

Conclusion:

We believe that a phenotype-independent protective ventilation strategy defined according to compliance is appropriate in patients with COVID-19-associated ARDS.

Keywords: COVID-19, acute respiratory distress syndrome, mechanical ventilation, phenotype

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Copyright and license

Copyright © 2022 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite?

1.
Kömürcü Ö, Küllaç S, Yılmaz A, Ülger F. COVİD-19 Akut Respiratuvar Distres Sendromu Fenotiplerinde Mekanik Ventilasyon. Turk J Intensive Care. 2022;20:126-134. https://doi.org/10.4274/tybd.galenos.2022.30301