Öz
Giriş ve Amaç: Koronavirus hastalığı-2019 (COVID-19) olan kritik hastalarda Air-Leak (AL) sendromunu önceden tahmin edebilmek ve risk faktörlerini bilmek morbidite ve mortaliteyi azaltabilir. Bu çalışmada, thoraks bilgisayarlı tomografi şiddet skorunun (CT-SS), AL gelişimini tahmin edip edemediğini araştırmayı amaçladık.
Yöntem ve Gereçler: COVID-19 hastaları, AL sendromu gelişip gelişmemesine göre iki gruba ayrıldı. Tüm hastalar için CT-SS hesaplandı. CT-SS’nin AL sendromunun gelişmesinin öngörme gücü ve AL için olası risk faktörleri araştırıldı.
Bulgular: Çalışmaya dahil edilen 272 hastanın 52’sinde (%19.1) AL sendromu gelişti. Medyan CT-SS Grup AL’da anlamlı derecede yüksekti. Grup AL’de CT-SS değeri 19(2-25), AL olmayan Grupda ise 13(1-25) idi (p değeri <0.001). CT-SS, AL oluşumunu tahmin etmede iyi tanısal performansa sahip olduğu tespit edildi (p<0.001). Grupların yoğun bakım mortalitesi karşılaştırıldığında AL olmayan grupta %42.3, AL grubunda ise %88.5 olduğu görüldü.
Tartışma ve Sonuç: CT-SS, COVID-19 ile beraber görülen AL sendromunun gelişiminde öngörme potansiyeli olabilir. Ancak bu konuda daha ileri çalışmalara ihtiyaç vardır.
Anahtar Kelimeler: COVID-19, yoğun bakım ünitesi, air-leak sendromu, BT şiddet skoru, mortalite
Referanslar
- Shahsavarinia K, Rahvar G, Soleimanpour H, Saadati M, Vahedi L, Mahmoodpoor A. Spontaneous pneumomediastinum, pneumothorax and subcutaneous emphysema in critically ill COVID-19 patients: A systematic review. Pak J Med Sci. 2022;38:730-5. https://doi.org/10.12669/pjms.38.3.5529
- Ochani R, Asad A, Yasmin F, et al. COVID-19 pandemic: from origins to outcomes. A comprehensive review of viral pathogenesis, clinical manifestations, diagnostic evaluation, and management. Infez Med. 2021;29:20-36.
- Quincho-Lopez A, Quincho-Lopez DL, Hurtado-Medina FD. Case Report: Pneumothorax and Pneumomediastinum as Uncommon Complications of COVID-19 Pneumonia-Literature Review. Am J Trop Med Hyg. 2020;103:1170-6. https://doi.org/10.4269/ajtmh.20-0815
- Adeyinka A, Pierre L. Air Leak. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.
- Akboga SA, Gokce A, Hatipoglu M, et al. The relationship between mortality and inflammatory markers and the systemic immune inflammatory index in patients in the intensive care unit with a pneumothorax as a complication of COVID-19 disease. Ir J Med Sci. 2022;191:1931-6. https://doi.org/10.1007/s11845-021-02740-x
- Brito J, Gregório P, Mariani A, et al. Pneumomediastinum in COVID-19 disease: Outcomes and relation to the Macklin effect. Asian Cardiovasc Thorac Ann. 2021;29:541-8. https://doi.org/10.1177/02184923211010089
- Marsico S, Del Carpio Bellido LA, Zuccarino F. Spontaneous Pneumomediastinum and Macklin Effect in COVID-19 Patients. Arch Bronconeumol. 2021;57:67. https://doi.org/10.1016/j.arbres.2020.07.030
- Elhakim TS, Abdul HS, Pelaez Romero C, Rodriguez-Fuentes Y. Spontaneous pneumomediastinum, pneumothorax and subcutaneous emphysema in COVID-19 pneumonia: a rare case and literature review. BMJ Case Rep. 2020;13:e239489. https://doi.org/10.1136/bcr-2020-239489
- Alsharif W, Qurashi A. Effectiveness of COVID-19 diagnosis and management tools: A review. Radiography (Lond). 2021;27:682-7. https://doi.org/10.1016/j.radi.2020.09.010
- Simpson S, Kay FU, Abbara S, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication. J Thorac Imaging. 2020;35:219-27. https://doi.org/10.1097/RTI.0000000000000524
- Chang YC, Yu CJ, Chang SC, et al. Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT. Radiology. 2005;236:1067-75. https://doi.org/10.1148/radiol.2363040958
- Juneja D, Kataria S, Singh O. Air leaks in COVID-19. World J Virol. 2022;11:176-85. https://doi.org/10.5501/wjv.v11.i4.176
- Ebrahimi A, Yousefifard M, Mohammad Kazemi H, et al. Diagnostic Accuracy of Chest Ultrasonography versus Chest Radiography for Identification of Pneumothorax: A Systematic Review and Meta-Analysis. Tanaffos. 2014;13:29-40.
- Rollas K, Çalışkan T, Yavuz T, Güldoğan IK. Pneumothorax and Pneumomediastinum in Patients admitted to Intensive Care Unit with COVID-19 Pneumonia: A Single-Center Retrospective Analysis. Journal of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care Society. 2022;28:178-83. https://doi.org/10.14744/GKDAD.2022.54366
- Zakariaee SS, Salmanipour H, Naderi N, Kazemi-Arpanahi H, Shanbehzadeh M. Association of chest CT severity score with mortality of COVID-19 patients: a systematic review and meta-analysis. Clin Transl Imaging. 2022;10:663-76. https://doi.org/10.1007/s40336-022-00512-w
- Aziz-Ahari A, Keyhanian M, Mamishi S, et al. Chest CT severity score: assessment of COVID‑19 severity and short-term prognosis in hospitalized Iranian patients. Wien Med Wochenschr. 2022;172:77-83. https://doi.org/10.1007/s10354-022-00914-5
- Simioli F, Annunziata A, Polistina GE, Coppola A, Di Spirito V, Fiorentino G. The Role of High Flow Nasal Cannula in COVID-19 Associated Pneumomediastinum and Pneumothorax. Healthcare (Basel). 2021;9:620. https://doi.org/10.3390/healthcare9060620
- Kayhan O, Demirkıran O, Ürkmez S, Dikmen Y. Air leaks in COVID-19 pneumonia. Turk Gogus Kalp Damar Cerrahisi Derg. 2022;30:281-5. https://doi.org/10.5606/tgkdc.dergisi.2022.20763
- Nasa P, Juneja D, Jain R. Air leak with COVID-19 - A meta-summary. Asian Cardiovasc Thorac Ann. 2022;30:237-44. https://doi.org/10.1177/02184923211031134
- Jones E, Gould A, Pillay TD, et al. Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax in Critically Ill Patients With Coronavirus Disease 2019: A Retrospective Cohort Study. Crit Care Explor. 2020;2:e0210. https://doi.org/10.1097/CCE.0000000000000210
- Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420-2. https://doi.org/10.1016/S2213-2600(20)30076-X
- Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol. 2020;215:87-93. https://doi.org/10.2214/AJR.20.23034
- Esnault P, Cardinale M, Hraiech S, et al. High Respiratory Drive and Excessive Respiratory Efforts Predict Relapse of Respiratory Failure in Critically Ill Patients with COVID-19. Am J Respir Crit Care Med. 2020;202:1173-8. https://doi.org/10.1164/rccm.202005-1582LE
- Marini JJ, Gattinoni L. Management of COVID-19 Respiratory Distress. JAMA. 2020;323:2329-30. https://doi.org/10.1001/jama.2020.6825
- Battaglini D, Robba C, Ball L, et al. Noninvasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review. Br J Anaesth. 2021;127:353-64. https://doi.org/10.1016/j.bja.2021.05.024
- Pinto EF, Santos RS, Antunes MA, et al. Static and Dynamic Transpulmonary Driving Pressures Affect Lung and Diaphragm Injury during Pressure-controlled versus Pressure-support Ventilation in Experimental Mild Lung Injury in Rats. Anesthesiology. 2020;132:307-20. https://doi.org/10.1097/ALN.0000000000003060
- Tonelli R, Bruzzi G, Manicardi L, et al. Risk Factors for Pulmonary Air Leak and Clinical Prognosis in Patients With COVID-19 Related Acute Respiratory Failure: A Retrospective Matched Control Study. Front Med (Lausanne). 2022;9:848639. https://doi.org/10.3389/fmed.2022.848639
- Pun BT, Badenes R, Heras La Calle G, et al. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med. 2021;9:239-50. https://doi.org/10.1016/S2213-2600(20)30552-X
- Boussarsar M, Protti A. Pulmonary air leak in COVID-19: time to learn from our mistakes. Intensive Care Med. 2022;48:1614-6. https://doi.org/10.1007/s00134-022-06866-z
- Zantah M, Dominguez Castillo E, Townsend R, Dikengil F, Criner GJ. Pneumothorax in COVID-19 disease- incidence and clinical characteristics. Respir Res. 2020;21:236. https://doi.org/10.1186/s12931-020-01504-y
- Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8:475-81. https://doi.org/10.1016/S2213-2600(20)30079-5
- Knox DB, Brunhoeber A, Peltan ID, Brown SM, Lanspa MJ. Comparison of radiographic pneumothorax and pneumomediastinum in COVID-19 vs. non-COVID-19 acute respiratory distress syndrome. Intensive Care Med. 2022;48:1648-51. https://doi.org/10.1007/s00134-022-06816-9
- Housman B, Jacobi A, Carollo A, et al. COVID-19 ventilator barotrauma management: less is more. Ann Transl Med. 2020;8:1575. https://doi.org/10.21037/atm-20-3907
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