Abstract

Objective:

In our study, we aimed to investigate the effect of hypothermia on survival, C-reactive protein (CRP), procalcitonin and leukocyte levels in rat models, induced with cecal ligation-perforation procedure.

Materials and Methods:

After formation of the sepsis, the rats were randomized as hypothermic sham, septic (32 °C-34 °C) and normothermic sham, septic (36 °C-38 °C). At the beginning of study (0 h) and at 6th hour blood was taken from all rats in all groups; CRP, procalcitonin, leukocyte levels were measured and the survival time of rats in all groups was recorded.

Results:

A statistically significant difference was found between the hypothermic and normothermic septic group in terms of survival time (hypothermic septic 24.3±20.2, normothermic septic group 15.9±13.5 h, p=0.039). There was no statistically significant difference for time dependent changes of CRP and procalcitonin all groups.

Conclusion:

It can be suggested that hypothermia in experimental sepsis might have positive effects on survival but the effect on the markers of infection is unclear and further studies are needed.

Keywords: Hypothermia, experimental, Rat model, sepsis

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Copyright and license

Copyright © 2019 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite?

1.
Karaca İ, Çankayalı İ, Demirağ K, Uyar M. Protective Effect of Hypothermia During Experimental Sepsis. Turk J Intensive Care. 2019;17(2):82-87. https://doi.org/10.4274/tybd.galenos.2018.76094