Quetiapine is an antipsychotic commonly used in treatment of depression, bipolar disorders and schizophrenia. Quetiapine interacts with several receptors present in the central nervous system and therefore may cause diverse side effects like somnolence, coma or hyperglycemia. By prolonging QT interval, quetiapine may predispose the patient to tachycardia and other cardiac dysrhythmias and even cardiac arrest. Due to its antagonism on histaminergic receptors, quetiapine may cause respiratory depression and coma, necessitating mechanical ventilation support. On this paper, we discussed the management of an 80 year old male who is suspected to present with coma following quetiapine administration.

Keywords: Quetiapine, cardiac arrest, coma